The John O’Brien Nanofabrication Laboratory acts as an innovation hub for a diverse range of research activities spanning from basic science to applied technology. The facility contains lithography, characterization (surface, optical, electrical), imaging, and device integration resources. It also contains multiple growth and deposition systems, allowing separate toolsets for conventional and unconventional material systems. Enabling interdisciplinary research with next generation nanomaterials is a strong focus of the facility. This emphasis is unique among nanofabrication facilities and enables researchers to translate novel materials into transformational devices for a wide range of applications.